PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

[2H]C1([2H])C(=O)NC(=O)C([2H])(n2cc(-c3ccc(-c4cc(C)c(C)c(N)n4)cc3F)oc2=O)C1([2H])[2H]

Compound summary

Compound IDPGDB_C009145

FormulaC21H19FN4O4

Molecular weight415.436

InChIKeyPKEKMIKJWMHBLO-HXVTVHMQSA-N

Physicochemical properties

Exact mass415.1704

RDKit cLogP2.49

TPSA120.2

HBD / HBA2 / 7

Rotatable bonds3

Heavy atoms30

Hetero atoms9

Rings / aromatic4 / 3

Fraction Csp30.24

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	88	%	-	13 d	IKZF2	-	-	US20250129061A1	PGDB_A009698	PGDB_C009145	PGDB_AS001547	View
DC50	-	=	139	nM	-	—	IKZF1	-	-	US20250129061A1	PGDB_A015321	PGDB_C009145	PGDB_AS000255	View
Dmax	-	=	71	%	-	-	IKZF3	-	-	US20250129061A1	PGDB_A017982	PGDB_C009145	PGDB_AS001745	View
Dmax	-	=	71	%	Concentration context: titrated doses	24 h	IKZF3	-	-	US20250129061A1	PGDB_A018371	PGDB_C009145	PGDB_AS001021	View
Dmax	-	=	88	%	-	-	IKZF2	-	-	US20250129061A1	PGDB_A022687	PGDB_C009145	PGDB_AS001318	View
DC50	-	=	26	nM	-	—	IKZF3	-	-	US20250129061A1	PGDB_A024060	PGDB_C009145	PGDB_AS001957	View
Dmax	-	=	66	%	-	-	IKZF1	-	-	US20250129061A1	PGDB_A029033	PGDB_C009145	PGDB_AS000475	View
Dmax	-	=	66	%	Concentration context: titrated doses of compound	24 h	IKZF1	-	-	US20250129061A1	PGDB_A036517	PGDB_C009145	PGDB_AS001411	View
Dmax	-	=	96	%	-	-	IKZF4	-	-	US20250129061A1	PGDB_A049666	PGDB_C009145	PGDB_AS001833	View
DC50	-	=	0.63	nM	-	—	IKZF4	-	-	US20250129061A1	PGDB_A069716	PGDB_C009145	PGDB_AS002356	View
Dmax	-	=	96	%	Concentration context: titrated doses	13 d	IKZF4	-	-	US20250129061A1	PGDB_A070731	PGDB_C009145	PGDB_AS000732	View
DC50	-	=	42	nM	-	—	IKZF2	-	-	US20250129061A1	PGDB_A073336	PGDB_C009145	PGDB_AS000731	View

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