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SIMM · NJU
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SIMM · NJU
Patent
US20250129061A1
4 compounds
70 activity records
22 assays
Patent summary
Publication number
US20250129061A1
Assignee
Bristol Myers Squibb
Title
Substituted phenyl oxazolone compounds
Family ID
91302477
Family members
15
Family patent IDs
AU2024267385A1
CL2025003313A1
CN121057732A
CO2025015188A2
EP4511371A1
IL324452A
JP2026501039A
JP7829802B2
KR20250019700A
MX2025013042A
PE20260451A1
TW202500139A
US12331045B2
US20250129061A1
WO2024233514A1
Filing year
2024
Publication date
2025-04-24
Jurisdiction
US
Compounds
4
Activity records
70
Assays
22
Activity compounds and values
Activity records
70 records
Structure
Metric
Control
Relation
Value
Unit
Concentration
Time
Target
E3
Cell line
Record ID
Compound
Assay
Details
Dmax
-
=
1
%
-
-
IKZF2
-
-
PGDB_A009448
PGDB_C007372
PGDB_AS001318
View
Dmax
-
=
88
%
-
13 d
IKZF2
-
-
PGDB_A009698
PGDB_C009145
PGDB_AS001547
View
Dmax
-
=
74
%
-
-
IKZF1
-
-
PGDB_A011569
PGDB_C007372
PGDB_AS000475
View
Dmax
-
=
11
%
-
-
IKZF4
-
-
PGDB_A012502
PGDB_C007373
PGDB_AS001833
View
Dmax
-
=
15
%
-
72 h
IKZF3
-
Jurkat
PGDB_A012987
PGDB_C007373
PGDB_AS001493
View
Dmax
-
=
46
%
-
72 h
IKZF3
-
Jurkat
PGDB_A013555
PGDB_C007372
PGDB_AS001493
View
DC50
-
=
13.6
nM
-
—
IKZF2
-
Jurkat
PGDB_A013686
PGDB_C009144
PGDB_AS001143
View
Dmax
-
=
0
%
Concentration context: titrated doses
13 d
IKZF4
-
-
PGDB_A013796
PGDB_C007372
PGDB_AS000732
View
DC50
-
=
1520
nM
-
—
IKZF1
-
Jurkat
PGDB_A013830
PGDB_C007372
PGDB_AS002138
View
DC50
-
=
139
nM
-
—
IKZF1
-
-
PGDB_A015321
PGDB_C009145
PGDB_AS000255
View
DC50
-
>
10000
nM
-
—
IKZF3
-
Jurkat
PGDB_A016906
PGDB_C007373
PGDB_AS000744
View
Dmax
-
=
73
%
-
-
IKZF4
-
-
PGDB_A017317
PGDB_C009144
PGDB_AS001833
View
Dmax
-
=
0
%
-
-
IKZF3
-
-
PGDB_A017873
PGDB_C007373
PGDB_AS001745
View
Dmax
-
=
71
%
-
-
IKZF3
-
-
PGDB_A017982
PGDB_C009145
PGDB_AS001745
View
Dmax
-
=
71
%
Concentration context: titrated doses
24 h
IKZF3
-
-
PGDB_A018371
PGDB_C009145
PGDB_AS001021
View
DC50
-
=
113
nM
-
—
IKZF1
-
-
PGDB_A018378
PGDB_C007372
PGDB_AS000255
View
Dmax
-
=
74
%
Concentration context: titrated doses of compound
24 h
IKZF1
-
-
PGDB_A018920
PGDB_C007372
PGDB_AS001411
View
DC50
-
>
1000
nM
-
—
IKZF4
-
-
PGDB_A019349
PGDB_C007373
PGDB_AS002356
View
DC50
-
=
4915
nM
-
—
IKZF3
-
Jurkat
PGDB_A020520
PGDB_C009144
PGDB_AS000744
View
Dmax
-
=
88
%
-
-
IKZF2
-
-
PGDB_A022687
PGDB_C009145
PGDB_AS001318
View
