PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

COC1CCN(Cc2ccc(-c3ccc(-c4cn(C5CCC(=O)NC5=O)c(=O)o4)c(F)c3)nc2N)CC1

Compound summary

Compound IDPGDB_C010128

FormulaC26H28FN5O5

Molecular weight509.538

InChIKeySQGFGLKDMPXDDJ-UHFFFAOYSA-N

Physicochemical properties

Exact mass509.2074

RDKit cLogP2.48

TPSA132.7

HBD / HBA2 / 9

Rotatable bonds6

Heavy atoms37

Hetero atoms11

Rings / aromatic5 / 3

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

26 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
DC50	-	=	15	nM	-	—	-	-	primary human PBMC	WO2025049840	PGDB_A007030	PGDB_C010128	PGDB_AS001952	View
Dmax	-	=	77	%	-	-	IKZF3	-	-	WO2025049840	PGDB_A007335	PGDB_C010128	PGDB_AS001160	View
Dmax	-	=	91	%	-	-	IKZF2	-	Jurkat	WO2025049840	PGDB_A008259	PGDB_C010128	PGDB_AS000207	View
DC50	-	=	34	nM	-	—	IKZF2	-	Jurkat	WO2025049840	PGDB_A008896	PGDB_C010128	PGDB_AS002487	View
Dmax	-	=	69	%	-	24 h	IKZF1	-	Jurkat	WO2025049840	PGDB_A011542	PGDB_C010128	PGDB_AS000717	View
Dmax	-	=	98	%	-	20 h	IKZF2	-	-	WO2025049840	PGDB_A015776	PGDB_C010128	PGDB_AS002476	View
Dmax	-	=	66	%	-	13 d	IKZF2	-	-	WO2025049840	PGDB_A016671	PGDB_C010128	PGDB_AS001641	View
% Degradation	-	=	77	%	Concentration context: titrated doses	24 h	-	-	primary human PBMC	WO2025049840	PGDB_A018488	PGDB_C010128	PGDB_AS001028	View
DC50	-	>	10000	nM	-	—	IKZF3	-	-	WO2025049840	PGDB_A019234	PGDB_C010128	PGDB_AS001695	View
% Degradation	-	=	80	%	Concentration context: titrated doses	24 h	IKZF1	-	-	WO2025049840	PGDB_A024027	PGDB_C010128	PGDB_AS000316	View
DC50	-	=	3788	nM	-	—	IKZF1	-	-	WO2025049840	PGDB_A025461	PGDB_C010128	PGDB_AS001718	View
Dmax	-	=	35	%	-	20 h	IKZF3	-	-	WO2025049840	PGDB_A026254	PGDB_C010128	PGDB_AS001955	View
Dmax	-	=	80	%	-	-	IKZF4	-	-	WO2025049840	PGDB_A034270	PGDB_C010128	PGDB_AS001208	View
Dmax	-	=	80	%	-	13 d	IKZF4	-	-	WO2025049840	PGDB_A039356	PGDB_C010128	PGDB_AS000200	View
Dmax	-	=	61	%	-	24 h	IKZF3	-	Jurkat	WO2025049840	PGDB_A041678	PGDB_C010128	PGDB_AS000726	View
Dmax	-	=	67	%	-	20 h	IKZF1	-	-	WO2025049840	PGDB_A042000	PGDB_C010128	PGDB_AS001762	View
DC50	-	=	18	nM	-	—	IKZF3	-	-	WO2025049840	PGDB_A046089	PGDB_C010128	PGDB_AS002428	View
DC50	-	=	59	nM	-	—	IKZF2	-	-	WO2025049840	PGDB_A048577	PGDB_C010128	PGDB_AS000215	View
DC50	-	=	3005	nM	-	—	IKZF3	-	Jurkat	WO2025049840	PGDB_A054043	PGDB_C010128	PGDB_AS000098	View
Dmax	-	=	62	%	-	20 h	IKZF4	-	-	WO2025049840	PGDB_A058696	PGDB_C010128	PGDB_AS000341	View

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