PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Nc1nc(-c2ccc3c(c2F)CN(C2CCC(=O)NC2=O)C3=O)ccc1CN1CC(c2ccc(F)cn2)C1

Compound summary

Compound IDPGDB_C010130

FormulaC27H24F2N6O3

Molecular weight518.524

InChIKeyFJGBXYZGWNTVFW-UHFFFAOYSA-N

Physicochemical properties

Exact mass518.1878

RDKit cLogP2.36

TPSA121.5

HBD / HBA2 / 7

Rotatable bonds5

Heavy atoms38

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

26 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	86	%	-	24 h	IKZF1	-	-	WO2025064197	PGDB_A011216	PGDB_C010130	PGDB_AS002368	View
DC50	-	=	16	nM	-	—	IKZF1	-	-	WO2025064197	PGDB_A015607	PGDB_C010130	PGDB_AS000591	View
Dmax	-	=	39	%	-	20 h	IKZF3	-	-	WO2025064197	PGDB_A016044	PGDB_C010130	PGDB_AS001828	View
Dmax	-	=	100	%	-	20 h	IKZF2	-	-	WO2025064197	PGDB_A016865	PGDB_C010130	PGDB_AS001254	View
DC50	-	>	10000	nM	-	—	IKZF4	-	-	WO2025064197	PGDB_A020289	PGDB_C010130	PGDB_AS001282	View
Dmax	-	=	78	%	Concentration context: titrated doses	13 d	IKZF4	-	-	WO2025064197	PGDB_A023545	PGDB_C010130	PGDB_AS000221	View
Dmax	-	=	47	%	-	24 h	IKZF3	-	Jurkat	WO2025064197	PGDB_A026282	PGDB_C010130	PGDB_AS002580	View
DC50	-	=	11	nM	-	—	IKZF2	-	Jurkat	WO2025064197	PGDB_A027163	PGDB_C010130	PGDB_AS001529	View
DC50	-	=	21	nM	-	—	IKZF2	-	-	WO2025064197	PGDB_A030834	PGDB_C010130	PGDB_AS001515	View
Dmax	-	=	86	%	-	24 h	-	-	primary human PBMC	WO2025064197	PGDB_A030985	PGDB_C010130	PGDB_AS001406	View
Dmax	-	=	71	%	-	24 h	IKZF3	-	-	WO2025064197	PGDB_A032302	PGDB_C010130	PGDB_AS000033	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	WO2025064197	PGDB_A040263	PGDB_C010130	PGDB_AS002122	View
Dmax	-	=	67	%	-	24 h	IKZF1	-	Jurkat	WO2025064197	PGDB_A040949	PGDB_C010130	PGDB_AS001342	View
DC50	-	>	10000	nM	-	—	IKZF3	-	-	WO2025064197	PGDB_A046764	PGDB_C010130	PGDB_AS001891	View
DC50	-	=	1	nM	-	—	IKZF4	-	-	WO2025064197	PGDB_A052007	PGDB_C010130	PGDB_AS001710	View
Dmax	-	=	71	%	-	13 d	IKZF2	-	-	WO2025064197	PGDB_A058642	PGDB_C010130	PGDB_AS000562	View
Dmax	-	=	77	%	-	20 h	IKZF1	-	-	WO2025064197	PGDB_A059150	PGDB_C010130	PGDB_AS001941	View
DC50	-	=	83	nM	-	—	IKZF3	-	-	WO2025064197	PGDB_A060410	PGDB_C010130	PGDB_AS000410	View
Dmax	-	=	71	%	-	24 h	-	-	primary human PBMC	WO2025064197	PGDB_A066567	PGDB_C010130	PGDB_AS000355	View
Dmax	-	=	78	%	-	24 h	IKZF4	-	-	WO2025064197	PGDB_A069590	PGDB_C010130	PGDB_AS001570	View

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