PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

C=C1c2ccc(-c3ccc(CN4CC(c5ncc(F)cn5)C4)c(N)n3)c(F)c2CN1C1CCC(=O)NC1=O

Compound summary

Compound IDPGDB_C010132

FormulaC27H25F2N7O2

Molecular weight517.54

InChIKeyGTORSYLSHANUNO-UHFFFAOYSA-N

Physicochemical properties

Exact mass517.2038

RDKit cLogP2.59

TPSA117.3

HBD / HBA2 / 8

Rotatable bonds5

Heavy atoms38

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

26 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	68	%	-	24 h	IKZF3	-	-	WO2025064197	PGDB_A011285	PGDB_C010132	PGDB_AS000033	View
DC50	-	>	6136	nM	-	—	IKZF3	-	Jurkat	WO2025064197	PGDB_A012629	PGDB_C010132	PGDB_AS002122	View
Dmax	-	=	33	%	-	20 h	IKZF4	-	-	WO2025064197	PGDB_A015243	PGDB_C010132	PGDB_AS001958	View
DC50	-	=	2860	nM	-	—	IKZF1	-	Jurkat	WO2025064197	PGDB_A021226	PGDB_C010132	PGDB_AS002379	View
Dmax	-	=	71	%	-	24 h	-	-	primary human PBMC	WO2025064197	PGDB_A022229	PGDB_C010132	PGDB_AS001406	View
Dmax	-	=	73	%	Concentration context: titrated doses	13 d	IKZF4	-	-	WO2025064197	PGDB_A022686	PGDB_C010132	PGDB_AS000221	View
Dmax	-	=	11	%	-	20 h	IKZF3	-	-	WO2025064197	PGDB_A027423	PGDB_C010132	PGDB_AS001828	View
Dmax	-	=	100	%	-	20 h	IKZF2	-	-	WO2025064197	PGDB_A027566	PGDB_C010132	PGDB_AS001254	View
DC50	-	=	17	nM	-	—	IKZF2	-	Jurkat	WO2025064197	PGDB_A029279	PGDB_C010132	PGDB_AS001529	View
DC50	-	=	1024	nM	-	—	IKZF1	-	-	WO2025064197	PGDB_A033027	PGDB_C010132	PGDB_AS002472	View
Dmax	-	=	72	%	-	13 d	IKZF2	-	-	WO2025064197	PGDB_A037402	PGDB_C010132	PGDB_AS000562	View
Dmax	-	=	89	%	-	24 h	IKZF2	-	Jurkat	WO2025064197	PGDB_A038060	PGDB_C010132	PGDB_AS001517	View
Dmax	-	=	73	%	-	24 h	IKZF4	-	-	WO2025064197	PGDB_A043105	PGDB_C010132	PGDB_AS001570	View
DC50	-	>	10000	nM	-	—	IKZF3	-	-	WO2025064197	PGDB_A048578	PGDB_C010132	PGDB_AS001891	View
DC50	-	=	17	nM	-	—	IKZF2	-	-	WO2025064197	PGDB_A049377	PGDB_C010132	PGDB_AS001597	View
Dmax	-	=	39	%	-	24 h	IKZF3	-	Jurkat	WO2025064197	PGDB_A049845	PGDB_C010132	PGDB_AS002580	View
Dmax	-	=	68	%	-	24 h	-	-	primary human PBMC	WO2025064197	PGDB_A050143	PGDB_C010132	PGDB_AS000355	View
DC50	-	=	40	nM	-	—	IKZF2	-	-	WO2025064197	PGDB_A052077	PGDB_C010132	PGDB_AS001515	View
DC50	-	=	3	nM	-	—	IKZF4	-	-	WO2025064197	PGDB_A052133	PGDB_C010132	PGDB_AS001710	View
Dmax	-	=	71	%	-	24 h	IKZF1	-	-	WO2025064197	PGDB_A054853	PGDB_C010132	PGDB_AS002368	View

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