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Compound
PGDB_C011216
11 activity records1 related patents
2D structure
COC[C@@H]1CN(Cc2cc(F)c3nc(C45C6C7C4C4C5C6C74C(C)(C)O)ccc3c2)C[C@H]1Oc1ccc2c(c1)CN([C@H]1CCC(=O)NC1=O)C2=OCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EC50 | - | = | 0.023 | uM | - | — | WEE1 | - | MDA-MB-231 | WO2025137053A1 | PGDB_A012384 | PGDB_C011216 | PGDB_AS001832 | View |
| EC50 | - | = | 0.002 | uM | - | — | WEE1 | - | MKN45 | WO2025137053A1 | PGDB_A023536 | PGDB_C011216 | PGDB_AS002043 | View |
| EC50 | - | = | 0.002 | uM | - | — | WEE1 | - | 293T-LentiXWEE1-ePL | WO2025137053A1 | PGDB_A043677 | PGDB_C011216 | PGDB_AS001798 | View |
| Ymin | - | = | 22 | % | Concentration series: 1 uM, 10 uM | 4 h | WEE1 | - | 293T-LentiXWEE1-ePL | WO2025137053A1 | PGDB_A049241 | PGDB_C011216 | PGDB_AS001848 | View |
| Ymin | - | = | 7.5 | % | Concentration series: 1 uM, 10 uM | 120 h | WEE1 | - | MKN45 | WO2025137053A1 | PGDB_A050951 | PGDB_C011216 | PGDB_AS000997 | View |
| EC50 | - | = | 0.026 | uM | - | — | WEE1 | - | MDA-MB-231 | WO2025137053A1 | PGDB_A052577 | PGDB_C011216 | PGDB_AS001832 | View |
| EC50 | - | = | 0 | uM | - | — | WEE1 | - | 293T-LentiXWEE1-ePL | WO2025137053A1 | PGDB_A057427 | PGDB_C011216 | PGDB_AS001798 | View |
| Ymin | - | = | 13.2 | % | Concentration series: 1 uM, 10 uM | 120 h | WEE1 | - | MDA-MB-231 | WO2025137053A1 | PGDB_A063744 | PGDB_C011216 | PGDB_AS002525 | View |
| Ymin | - | = | 8.5 | % | Concentration series: 1 uM, 10 uM | 120 h | WEE1 | - | MKN45 | WO2025137053A1 | PGDB_A065738 | PGDB_C011216 | PGDB_AS000997 | View |
| Ymin | - | = | 18.7 | % | Concentration series: 1 uM, 10 uM | 4 h | WEE1 | - | 293T-LentiXWEE1-ePL | WO2025137053A1 | PGDB_A069969 | PGDB_C011216 | PGDB_AS001848 | View |
| Ymin | - | = | 59.3 | % | Concentration series: 1 uM, 10 uM | 120 h | WEE1 | - | MDA-MB-231 | WO2025137053A1 | PGDB_A071001 | PGDB_C011216 | PGDB_AS002525 | View |