PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CC=C(c5c[nH]c6ncccc56)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C014214

FormulaC25H24N6O3

Molecular weight456.506

InChIKeyPRXDDIQZDFABMV-UHFFFAOYSA-N

Physicochemical properties

Exact mass456.191

RDKit cLogP2.66

TPSA101.6

HBD / HBA2 / 5

Rotatable bonds4

Heavy atoms34

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.28

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A015139	PGDB_C014214	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A025435	PGDB_C014214	PGDB_AS000969	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A034356	PGDB_C014214	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A042224	PGDB_C014214	PGDB_AS001137	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A056855	PGDB_C014214	PGDB_AS001967	View
IC50	-	=	1000-5000	nM	-	—	-	-	Jurkat	WO2024245444A1	PGDB_A058772	PGDB_C014214	PGDB_AS001634	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A072701	PGDB_C014214	PGDB_AS000339	View
IC50	-	=	500-1000	nM	-	—	-	-	MM.1S	WO2024245444A1	PGDB_A075078	PGDB_C014214	PGDB_AS001978	View

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