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Compound
PGDB_C014217
8 activity records1 related patents
2D structure
O=C1CCN(N2Cc3cc(CN4CCN(C(c5cccc(F)c5)c5cccc(F)c5)CC4)ccc3C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 100-500 | nM | - | — | - | - | MM.1S | WO2024245444A1 | PGDB_A007374 | PGDB_C014217 | PGDB_AS001978 | View |
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | WEE1 | - | - | WO2024245444A1 | PGDB_A012806 | PGDB_C014217 | PGDB_AS001444 | View |
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF2 | - | - | WO2024245444A1 | PGDB_A015112 | PGDB_C014217 | PGDB_AS002298 | View |
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF3 | - | - | WO2024245444A1 | PGDB_A047752 | PGDB_C014217 | PGDB_AS001967 | View |
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | GSPT1 | - | - | WO2024245444A1 | PGDB_A048913 | PGDB_C014217 | PGDB_AS001137 | View |
| IC50 | - | = | 100-500 | nM | - | — | - | - | Jurkat | WO2024245444A1 | PGDB_A050101 | PGDB_C014217 | PGDB_AS001634 | View |
| % Degradation | - | < | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | CSNK1A1 | - | - | WO2024245444A1 | PGDB_A065586 | PGDB_C014217 | PGDB_AS000339 | View |
| % Degradation | - | < | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF1 | - | - | WO2024245444A1 | PGDB_A065772 | PGDB_C014217 | PGDB_AS000969 | View |