PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1cscc1C1=CCN(Cc2ccc3c(c2)CN(N2CCC(=O)NC2=O)C3=O)CC1

Compound summary

Compound IDPGDB_C014222

FormulaC23H24N4O3S

Molecular weight436.537

InChIKeyTXGVJZQKFKPSQS-UHFFFAOYSA-N

Physicochemical properties

Exact mass436.1569

RDKit cLogP3.16

TPSA73

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms31

Hetero atoms8

Rings / aromatic5 / 2

Fraction Csp30.35

Formal charge0

Fragments1

Activity compounds and values

Activity records

9 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	10-50	nM	-	—	-	-	MM.1S	WO2024245444A1	PGDB_A012758	PGDB_C014222	PGDB_AS001978	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A021830	PGDB_C014222	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A024621	PGDB_C014222	PGDB_AS000969	View
IC50	-	=	100-500	nM	-	—	-	-	Jurkat	WO2024245444A1	PGDB_A046777	PGDB_C014222	PGDB_AS001634	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A060724	PGDB_C014222	PGDB_AS001137	View
IC50	-	=	100-500	nM	-	—	-	-	MGC-803	WO2024245444A1	PGDB_A065070	PGDB_C014222	PGDB_AS000874	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A065830	PGDB_C014222	PGDB_AS001444	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A067209	PGDB_C014222	PGDB_AS002298	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A070563	PGDB_C014222	PGDB_AS000339	View

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