PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CCC(Nc5ccccc5-c5ccc(Cl)cc5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C014229

FormulaC30H30ClN5O3

Molecular weight544.055

InChIKeyKMYLKQJSOWDCJE-UHFFFAOYSA-N

Physicochemical properties

Exact mass543.2037

RDKit cLogP4.9

TPSA85

HBD / HBA2 / 5

Rotatable bonds6

Heavy atoms39

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

9 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A007609	PGDB_C014229	PGDB_AS002298	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A009113	PGDB_C014229	PGDB_AS000339	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A018679	PGDB_C014229	PGDB_AS001967	View
IC50	-	=	10-50	nM	-	—	-	-	MM.1S	WO2024245444A1	PGDB_A034036	PGDB_C014229	PGDB_AS001978	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A044209	PGDB_C014229	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A048730	PGDB_C014229	PGDB_AS001137	View
IC50	-	=	100-500	nM	-	—	-	-	Jurkat	WO2024245444A1	PGDB_A050560	PGDB_C014229	PGDB_AS001634	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A066546	PGDB_C014229	PGDB_AS000969	View
IC50	-	=	100-500	nM	-	—	-	-	MGC-803	WO2024245444A1	PGDB_A066740	PGDB_C014229	PGDB_AS000874	View

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