PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4C[C@@H]5C[C@H]4CN5c4cccc(Cl)c4Cl)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C014232

FormulaC24H23Cl2N5O3

Molecular weight500.386

InChIKeyUZVSYAIWHUAJBP-IRXDYDNUSA-N

Physicochemical properties

Exact mass499.1178

RDKit cLogP3.27

TPSA76.2

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms34

Hetero atoms10

Rings / aromatic6 / 2

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A009542	PGDB_C014232	PGDB_AS000339	View
IC50	-	=	1000-5000	nM	-	—	-	-	MM.1S	WO2024245444A1	PGDB_A022237	PGDB_C014232	PGDB_AS001978	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A022308	PGDB_C014232	PGDB_AS000969	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A053924	PGDB_C014232	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A058999	PGDB_C014232	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A060869	PGDB_C014232	PGDB_AS001137	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A063497	PGDB_C014232	PGDB_AS001967	View

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