PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CCN(c5cc(Cl)cc(Cl)c5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C014243

FormulaC23H23Cl2N5O3

Molecular weight488.375

InChIKeyHLZIWMGKAJYTBQ-UHFFFAOYSA-N

Physicochemical properties

Exact mass487.1178

RDKit cLogP3.13

TPSA76.2

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms33

Hetero atoms10

Rings / aromatic5 / 2

Fraction Csp30.35

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A016093	PGDB_C014243	PGDB_AS002298	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A019769	PGDB_C014243	PGDB_AS000969	View
IC50	-	=	100-500	nM	-	—	-	-	MV-4-11	WO2024245444A1	PGDB_A024783	PGDB_C014243	PGDB_AS002154	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A034197	PGDB_C014243	PGDB_AS000339	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A038471	PGDB_C014243	PGDB_AS001967	View
IC50	-	=	1000-5000	nM	-	—	-	-	Jurkat	WO2024245444A1	PGDB_A039626	PGDB_C014243	PGDB_AS001634	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A053521	PGDB_C014243	PGDB_AS001137	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A068394	PGDB_C014243	PGDB_AS001444	View

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