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Compound
PGDB_C014248
8 activity records1 related patents
2D structure
O=C1CCN(N2Cc3cc(CN4CCC(c5cccc(Cl)c5Cl)CC4)ccc3C2=O)C(=O)N1Compound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | GSPT1 | - | - | WO2024245444A1 | PGDB_A007435 | PGDB_C014248 | PGDB_AS001137 | View |
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF2 | - | - | WO2024245444A1 | PGDB_A010649 | PGDB_C014248 | PGDB_AS002298 | View |
| % Degradation | - | < | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | CSNK1A1 | - | - | WO2024245444A1 | PGDB_A019780 | PGDB_C014248 | PGDB_AS000339 | View |
| % Degradation | - | >= | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF1 | - | - | WO2024245444A1 | PGDB_A024665 | PGDB_C014248 | PGDB_AS000969 | View |
| IC50 | - | = | 1000-5000 | nM | - | — | - | - | Jurkat | WO2024245444A1 | PGDB_A030065 | PGDB_C014248 | PGDB_AS001634 | View |
| IC50 | - | = | 100-500 | nM | - | — | - | - | MV-4-11 | WO2024245444A1 | PGDB_A031480 | PGDB_C014248 | PGDB_AS002154 | View |
| % Degradation | - | < | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | WEE1 | - | - | WO2024245444A1 | PGDB_A054125 | PGDB_C014248 | PGDB_AS001444 | View |
| % Degradation | - | < | 20 | % | Concentration series: 500 nM, 50 nM | 24 h | IKZF3 | - | - | WO2024245444A1 | PGDB_A072729 | PGDB_C014248 | PGDB_AS001967 | View |