PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CC=C(c5cncc(Cl)c5Cl)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C014256

FormulaC23H21Cl2N5O3

Molecular weight486.359

InChIKeyYVDWHDLAGKYJIR-UHFFFAOYSA-N

Physicochemical properties

Exact mass485.1021

RDKit cLogP3.49

TPSA85.8

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms33

Hetero atoms10

Rings / aromatic5 / 2

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A012555	PGDB_C014256	PGDB_AS000339	View
IC50	-	=	1000-5000	nM	-	—	-	-	MM.1S	WO2024245444A1	PGDB_A033616	PGDB_C014256	PGDB_AS001978	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A036459	PGDB_C014256	PGDB_AS000969	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A036639	PGDB_C014256	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A056544	PGDB_C014256	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A056846	PGDB_C014256	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A067658	PGDB_C014256	PGDB_AS001137	View

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