PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1nc(N2CCN(Cc3ccc4c(c3)CN(N3CCC(=O)NC3=O)C4=O)CC2)c2ccsc2n1

Compound summary

Compound IDPGDB_C014266

FormulaC24H25N7O3S

Molecular weight491.577

InChIKeyBDAFCLPFKLBVIH-UHFFFAOYSA-N

Physicochemical properties

Exact mass491.174

RDKit cLogP2.13

TPSA102

HBD / HBA1 / 8

Rotatable bonds4

Heavy atoms35

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	40-60	%	500 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A014365	PGDB_C014266	PGDB_AS000199	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A022906	PGDB_C014266	PGDB_AS000969	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A026278	PGDB_C014266	PGDB_AS001444	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A026468	PGDB_C014266	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A035356	PGDB_C014266	PGDB_AS002298	View
% Inhibition	-	=	20-40	%	10 nM	-	-	-	H292	WO2024245444A1	PGDB_A051867	PGDB_C014266	PGDB_AS001605	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A055908	PGDB_C014266	PGDB_AS001137	View
% Inhibition	-	=	60-80	%	10 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A069791	PGDB_C014266	PGDB_AS001519	View
% Inhibition	-	=	20-40	%	500 nM	-	-	-	H292	WO2024245444A1	PGDB_A074417	PGDB_C014266	PGDB_AS000415	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A075420	PGDB_C014266	PGDB_AS000339	View

Rows per pagePage 1 of 1 · 10 recordsGo to page