PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2C(=O)c3ccc(CN4CC=C(c5ncnc6sc7c(c56)CCC7)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C014300

FormulaC27H24N6O4S

Molecular weight528.594

InChIKeyIMUSKLJRJUXZPP-UHFFFAOYSA-N

Physicochemical properties

Exact mass528.158

RDKit cLogP2.92

TPSA115.8

HBD / HBA1 / 8

Rotatable bonds4

Heavy atoms38

Hetero atoms11

Rings / aromatic7 / 3

Fraction Csp30.33

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	15-20	%	500 nM	-	-	-	H292	WO2024245444A1	PGDB_A008945	PGDB_C014300	PGDB_AS000415	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A013604	PGDB_C014300	PGDB_AS000969	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A028938	PGDB_C014300	PGDB_AS001967	View
% Inhibition	-	=	20-40	%	10 nM	-	-	-	H292	WO2024245444A1	PGDB_A033434	PGDB_C014300	PGDB_AS001605	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A042769	PGDB_C014300	PGDB_AS001137	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A045608	PGDB_C014300	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A048903	PGDB_C014300	PGDB_AS000339	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A072620	PGDB_C014300	PGDB_AS002298	View

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