PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CC=C(c5ncc6ccsc6n5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C014302

FormulaC24H22N6O3S

Molecular weight474.546

InChIKeyFWTIIEJQXNSQQZ-UHFFFAOYSA-N

Physicochemical properties

Exact mass474.1474

RDKit cLogP2.79

TPSA98.7

HBD / HBA1 / 7

Rotatable bonds4

Heavy atoms34

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.29

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	10-15	%	500 nM	-	-	-	H292	WO2024245444A1	PGDB_A008210	PGDB_C014302	PGDB_AS000415	View
% Inhibition	-	=	80-100	%	500 nM	-	-	-	MM.1S	WO2024245444A1	PGDB_A011808	PGDB_C014302	PGDB_AS000503	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A021397	PGDB_C014302	PGDB_AS002298	View
% Inhibition	-	=	20-40	%	10 nM	-	-	-	H292	WO2024245444A1	PGDB_A029695	PGDB_C014302	PGDB_AS001605	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A030945	PGDB_C014302	PGDB_AS000339	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A035263	PGDB_C014302	PGDB_AS001137	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A038250	PGDB_C014302	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A038706	PGDB_C014302	PGDB_AS001444	View
% Inhibition	-	=	20-30	%	10 nM	-	-	-	MM.1S	WO2024245444A1	PGDB_A062884	PGDB_C014302	PGDB_AS001568	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A073017	PGDB_C014302	PGDB_AS000969	View

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