PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1cc2c(N3CCN(Cc4ccc5c(c4)C(=O)N(N4CCC(=O)NC4=O)C5=O)CC3)ncnc2s1

Compound summary

Compound IDPGDB_C014330

FormulaC24H23N7O4S

Molecular weight505.56

InChIKeyOHULCBIZCRTGJC-UHFFFAOYSA-N

Physicochemical properties

Exact mass505.1532

RDKit cLogP1.77

TPSA119

HBD / HBA1 / 9

Rotatable bonds4

Heavy atoms36

Hetero atoms12

Rings / aromatic6 / 3

Fraction Csp30.33

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	30-40	%	500 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A011831	PGDB_C014330	PGDB_AS000199	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A014738	PGDB_C014330	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A026890	PGDB_C014330	PGDB_AS001444	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A030438	PGDB_C014330	PGDB_AS002298	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A034052	PGDB_C014330	PGDB_AS000969	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A053999	PGDB_C014330	PGDB_AS001137	View
% Inhibition	-	=	10-18	%	10 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A072575	PGDB_C014330	PGDB_AS001519	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A073023	PGDB_C014330	PGDB_AS000339	View

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