PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CCN(c5ncc6ccsc6n5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C014333

FormulaC23H23N7O3S

Molecular weight477.55

InChIKeyQCPPZXRABHZSHN-UHFFFAOYSA-N

Physicochemical properties

Exact mass477.1583

RDKit cLogP1.83

TPSA102

HBD / HBA1 / 8

Rotatable bonds4

Heavy atoms34

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.35

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	5-10	%	500 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A021471	PGDB_C014333	PGDB_AS002131	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A024757	PGDB_C014333	PGDB_AS001137	View
% Inhibition	-	=	18-25	%	10 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A026107	PGDB_C014333	PGDB_AS001519	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A034662	PGDB_C014333	PGDB_AS001967	View
% Inhibition	-	=	18-25	%	10 nM	-	-	-	MDA-MB-231	WO2024245444A1	PGDB_A051593	PGDB_C014333	PGDB_AS002156	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A062712	PGDB_C014333	PGDB_AS000339	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A067127	PGDB_C014333	PGDB_AS001444	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A067417	PGDB_C014333	PGDB_AS000969	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A067861	PGDB_C014333	PGDB_AS002298	View
% Inhibition	-	=	25-30	%	500 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A072268	PGDB_C014333	PGDB_AS000199	View

Rows per pagePage 1 of 1 · 10 recordsGo to page