PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2C(=O)c3ccc(CN4CCN(c5cc(Cl)ccn5)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C019965

FormulaC22H21ClN6O4

Molecular weight468.901

InChIKeyUDIBNQQMFXBWQP-UHFFFAOYSA-N

Physicochemical properties

Exact mass468.1313

RDKit cLogP1.51

TPSA106.2

HBD / HBA1 / 7

Rotatable bonds4

Heavy atoms33

Hetero atoms11

Rings / aromatic5 / 2

Fraction Csp30.32

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A008320	PGDB_C019965	PGDB_AS000969	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A009958	PGDB_C019965	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A010672	PGDB_C019965	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A010771	PGDB_C019965	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A012942	PGDB_C019965	PGDB_AS001137	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A013371	PGDB_C019965	PGDB_AS000969	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A029504	PGDB_C019965	PGDB_AS002298	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A029826	PGDB_C019965	PGDB_AS000339	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A041883	PGDB_C019965	PGDB_AS000339	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A042255	PGDB_C019965	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A057141	PGDB_C019965	PGDB_AS001137	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A063225	PGDB_C019965	PGDB_AS001444	View

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