PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1ccsc1C1=CCN(Cc2ccc3c(c2)C(=O)N(N2CCC(=O)NC2=O)C3=O)CC1

Compound summary

Compound IDPGDB_C019993

FormulaC23H22N4O4S

Molecular weight450.52

InChIKeyYYNARLJXMKXOAV-UHFFFAOYSA-N

Physicochemical properties

Exact mass450.1362

RDKit cLogP2.8

TPSA90

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms32

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

6 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A008986	PGDB_C019993	PGDB_AS000339	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A011211	PGDB_C019993	PGDB_AS001137	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A023139	PGDB_C019993	PGDB_AS001967	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A033861	PGDB_C019993	PGDB_AS000969	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A039879	PGDB_C019993	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A057801	PGDB_C019993	PGDB_AS002298	View

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