PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CCC(c5c[nH]c6ncccc56)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C020139

FormulaC25H26N6O3

Molecular weight458.522

InChIKeyRJCYMBPZXQLZIT-UHFFFAOYSA-N

Physicochemical properties

Exact mass458.2066

RDKit cLogP2.76

TPSA101.6

HBD / HBA2 / 5

Rotatable bonds4

Heavy atoms34

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.36

Formal charge0

Fragments1

Activity compounds and values

Activity records

6 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A008284	PGDB_C020139	PGDB_AS000969	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A009725	PGDB_C020139	PGDB_AS000339	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A029040	PGDB_C020139	PGDB_AS002298	View
% Degradation	-	<	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A044070	PGDB_C020139	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A059327	PGDB_C020139	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A077074	PGDB_C020139	PGDB_AS001137	View

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