PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CCN(c5cc(Cl)ccn5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C023603

FormulaC22H23ClN6O3

Molecular weight454.918

InChIKeyJLJATLNTVVUDQO-UHFFFAOYSA-N

Physicochemical properties

Exact mass454.152

RDKit cLogP1.87

TPSA89.1

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms32

Hetero atoms10

Rings / aromatic5 / 2

Fraction Csp30.36

Formal charge0

Fragments1

Activity compounds and values

Activity records

6 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A008756	PGDB_C023603	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A023844	PGDB_C023603	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A039149	PGDB_C023603	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A051984	PGDB_C023603	PGDB_AS001137	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A066769	PGDB_C023603	PGDB_AS000969	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A068160	PGDB_C023603	PGDB_AS000339	View

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