PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CCN(c5ccccc5Br)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C023611

FormulaC23H24BrN5O3

Molecular weight498.381

InChIKeyIUKUMXSSIBKDNZ-UHFFFAOYSA-N

Physicochemical properties

Exact mass497.1063

RDKit cLogP2.58

TPSA76.2

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms32

Hetero atoms9

Rings / aromatic5 / 2

Fraction Csp30.35

Formal charge0

Fragments1

Activity compounds and values

Activity records

7 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A014157	PGDB_C023611	PGDB_AS000339	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A018288	PGDB_C023611	PGDB_AS000969	View
IC50	-	=	1000-5000	nM	-	—	-	-	MV-4-11	WO2024245444A1	PGDB_A023390	PGDB_C023611	PGDB_AS002154	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A023989	PGDB_C023611	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A029151	PGDB_C023611	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A031415	PGDB_C023611	PGDB_AS001137	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A071253	PGDB_C023611	PGDB_AS001967	View

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