PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1cccc(N2CCN(Cc3ccc4c(c3)CN(N3CCC(=O)NC3=O)C4=O)CC2)c1

Compound summary

Compound IDPGDB_C023613

FormulaC24H27N5O3

Molecular weight433.512

InChIKeyPICJSGKDZNSXKE-UHFFFAOYSA-N

Physicochemical properties

Exact mass433.2114

RDKit cLogP2.13

TPSA76.2

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms32

Hetero atoms8

Rings / aromatic5 / 2

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
IC50	-	=	1000-5000	nM	-	—	-	-	MV-4-11	WO2024245444A1	PGDB_A014696	PGDB_C023613	PGDB_AS002154	View
IC50	-	=	1000-5000	nM	-	—	-	-	Jurkat	WO2024245444A1	PGDB_A040315	PGDB_C023613	PGDB_AS001634	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A046666	PGDB_C023613	PGDB_AS001137	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A053647	PGDB_C023613	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A060824	PGDB_C023613	PGDB_AS001967	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A062872	PGDB_C023613	PGDB_AS000969	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A064607	PGDB_C023613	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A077472	PGDB_C023613	PGDB_AS000339	View

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