PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cn1cc(C2CCN(Cc3ccc4c(c3)CN(N3CCC(=O)NC3=O)C4=O)CC2)c2ccc(F)cc21

Compound summary

Compound IDPGDB_C023617

FormulaC27H28FN5O3

Molecular weight489.551

InChIKeyMTJVQTNWOPKDAT-UHFFFAOYSA-N

Physicochemical properties

Exact mass489.2176

RDKit cLogP3.51

TPSA77.9

HBD / HBA1 / 5

Rotatable bonds4

Heavy atoms36

Hetero atoms9

Rings / aromatic6 / 3

Fraction Csp30.37

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A011988	PGDB_C023617	PGDB_AS000969	View
IC50	-	=	100-500	nM	-	—	-	-	MM.1S	WO2024245444A1	PGDB_A021044	PGDB_C023617	PGDB_AS001978	View
IC50	-	=	100-500	nM	-	—	-	-	Jurkat	WO2024245444A1	PGDB_A021889	PGDB_C023617	PGDB_AS001634	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A022903	PGDB_C023617	PGDB_AS001137	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A051056	PGDB_C023617	PGDB_AS000339	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A054693	PGDB_C023617	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A057090	PGDB_C023617	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A057340	PGDB_C023617	PGDB_AS001967	View

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