PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1cc2c(C3CCN(Cc4ccc5c(c4)C(=O)N(N4CCC(=O)NC4=O)C5=O)CC3)ncnc2s1

Compound summary

Compound IDPGDB_C023622

FormulaC25H24N6O4S

Molecular weight504.572

InChIKeyNHIHEPMBGGAYDU-UHFFFAOYSA-N

Physicochemical properties

Exact mass504.158

RDKit cLogP2.83

TPSA115.8

HBD / HBA1 / 8

Rotatable bonds4

Heavy atoms36

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.36

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A007160	PGDB_C023622	PGDB_AS000969	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A023068	PGDB_C023622	PGDB_AS000339	View
% Inhibition	-	=	10-15	%	500 nM	-	-	-	H292	WO2024245444A1	PGDB_A035223	PGDB_C023622	PGDB_AS000415	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A036586	PGDB_C023622	PGDB_AS001444	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A058243	PGDB_C023622	PGDB_AS002298	View
% Inhibition	-	=	30-40	%	10 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A061682	PGDB_C023622	PGDB_AS001519	View
% Inhibition	-	=	5-10	%	10 nM	-	-	-	H292	WO2024245444A1	PGDB_A068514	PGDB_C023622	PGDB_AS001605	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A071772	PGDB_C023622	PGDB_AS001137	View
% Inhibition	-	=	40-60	%	500 nM	-	-	-	MV-4-11	WO2024245444A1	PGDB_A074368	PGDB_C023622	PGDB_AS000199	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A077029	PGDB_C023622	PGDB_AS001967	View

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