PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Cc1nc(C2=CCN(Cc3ccc4c(c3)C(=O)N(N3CCC(=O)NC3=O)C4=O)CC2)c2c(-c3ccccc3)csc2n1

Compound summary

Compound IDPGDB_C023626

FormulaC31H26N6O4S

Molecular weight578.654

InChIKeyWEZSDLHATUNYDH-UHFFFAOYSA-N

Physicochemical properties

Exact mass578.1736

RDKit cLogP4.41

TPSA115.8

HBD / HBA1 / 8

Rotatable bonds5

Heavy atoms42

Hetero atoms11

Rings / aromatic7 / 4

Fraction Csp30.23

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	15-20	%	500 nM	-	-	-	H292	WO2024245444A1	PGDB_A010147	PGDB_C023626	PGDB_AS000415	View
% Inhibition	-	=	20-40	%	10 nM	-	-	-	H292	WO2024245444A1	PGDB_A012920	PGDB_C023626	PGDB_AS001605	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2024245444A1	PGDB_A015870	PGDB_C023626	PGDB_AS001444	View
% Inhibition	-	=	42-60	%	10 nM	-	-	-	MM.1S	WO2024245444A1	PGDB_A020722	PGDB_C023626	PGDB_AS001568	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	WO2024245444A1	PGDB_A032396	PGDB_C023626	PGDB_AS002298	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2024245444A1	PGDB_A057282	PGDB_C023626	PGDB_AS000339	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	WO2024245444A1	PGDB_A059298	PGDB_C023626	PGDB_AS000969	View
% Inhibition	-	=	20-30	%	500 nM	-	-	-	MM.1S	WO2024245444A1	PGDB_A064416	PGDB_C023626	PGDB_AS000503	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	WO2024245444A1	PGDB_A068124	PGDB_C023626	PGDB_AS001137	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2024245444A1	PGDB_A076769	PGDB_C023626	PGDB_AS001967	View

Rows per pagePage 1 of 1 · 10 recordsGo to page