PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NN4CCN(C(c5cccc(F)c5)c5cccc(F)c5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024281

FormulaC30H29F2N5O3

Molecular weight545.59

InChIKeyLVIKQDWPIJKUFP-UHFFFAOYSA-N

Physicochemical properties

Exact mass545.2238

RDKit cLogP3.46

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms40

Hetero atoms10

Rings / aromatic6 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A013471	PGDB_C024281	PGDB_AS000351	View
% Inhibition	-	=	10-20	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A015993	PGDB_C024281	PGDB_AS000245	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A034430	PGDB_C024281	PGDB_AS000689	View
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A061267	PGDB_C024281	PGDB_AS000857	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A063820	PGDB_C024281	PGDB_AS000091	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A070094	PGDB_C024281	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A071118	PGDB_C024281	PGDB_AS002453	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A075607	PGDB_C024281	PGDB_AS001726	View

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