PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3c(ccc(NN4CCN(C(c5cccc(F)c5)c5cccc(F)c5)CC4)c3F)C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024282

FormulaC30H28F3N5O3

Molecular weight563.58

InChIKeyYEMGZZAYTNWIOK-UHFFFAOYSA-N

Physicochemical properties

Exact mass563.2144

RDKit cLogP3.6

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms41

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.3

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	50-60	%	500 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A011546	PGDB_C024282	PGDB_AS000857	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A025067	PGDB_C024282	PGDB_AS000091	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A029525	PGDB_C024282	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A032663	PGDB_C024282	PGDB_AS002453	View
% Inhibition	-	=	0-10	%	10 nM	96 h	IKZF3	-	CFPAC-1	WO2025162225A1	PGDB_A046424	PGDB_C024282	PGDB_AS000245	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A050746	PGDB_C024282	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A066717	PGDB_C024282	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A074507	PGDB_C024282	PGDB_AS000750	View

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