PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(NN4CCN(C(c5cccc(F)c5)c5cccc(F)c5)CC4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C024283

FormulaC30H27F2N5O4

Molecular weight559.573

InChIKeyLNAXBVFGKZOQGX-UHFFFAOYSA-N

Physicochemical properties

Exact mass559.2031

RDKit cLogP3.1

TPSA102.1

HBD / HBA2 / 7

Rotatable bonds6

Heavy atoms41

Hetero atoms11

Rings / aromatic6 / 3

Fraction Csp30.27

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A034097	PGDB_C024283	PGDB_AS002453	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A035306	PGDB_C024283	PGDB_AS000689	View
% Inhibition	-	=	20-30	%	0.1 uM	-	IKZF3	-	-	WO2025162225A1	PGDB_A036877	PGDB_C024283	PGDB_AS002550	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A041522	PGDB_C024283	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A049699	PGDB_C024283	PGDB_AS000750	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A053203	PGDB_C024283	PGDB_AS001726	View
% Inhibition	-	=	20-30	%	0.1 uM	-	IKZF3	-	-	WO2025162225A1	PGDB_A063095	PGDB_C024283	PGDB_AS001671	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A064820	PGDB_C024283	PGDB_AS000091	View
% Inhibition	-	=	20-30	%	0.1 uM	-	IKZF3	-	-	WO2025162225A1	PGDB_A066786	PGDB_C024283	PGDB_AS000702	View
% Inhibition	-	=	10-20	%	0.1 uM	-	IKZF3	-	-	WO2025162225A1	PGDB_A074377	PGDB_C024283	PGDB_AS000994	View

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