PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC1(C)CC(c2ccc(Cl)cc2)=C(CN2CCN(Nc3ccc4c(c3)CN(C3CCC(=O)NC3=O)C4=O)CC2)CO1

Compound summary

Compound IDPGDB_C024288

FormulaC31H36ClN5O4

Molecular weight578.113

InChIKeyBNSSWGYQUWYBOY-UHFFFAOYSA-N

Physicochemical properties

Exact mass577.2456

RDKit cLogP3.7

TPSA94.2

HBD / HBA2 / 7

Rotatable bonds6

Heavy atoms41

Hetero atoms10

Rings / aromatic6 / 2

Fraction Csp30.45

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	20-30	%	1 uM	-	IKZF3	-	-	WO2025162225A1	PGDB_A007761	PGDB_C024288	PGDB_AS001874	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A008996	PGDB_C024288	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A011536	PGDB_C024288	PGDB_AS002453	View
% Inhibition	-	=	20-30	%	1 uM	-	IKZF3	-	-	WO2025162225A1	PGDB_A045027	PGDB_C024288	PGDB_AS001987	View
% Inhibition	-	=	20-30	%	1 uM	-	IKZF3	-	-	WO2025162225A1	PGDB_A049376	PGDB_C024288	PGDB_AS001458	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A049982	PGDB_C024288	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A054602	PGDB_C024288	PGDB_AS000689	View
% Inhibition	-	=	20-30	%	1 uM	-	IKZF3	-	-	WO2025162225A1	PGDB_A056484	PGDB_C024288	PGDB_AS000606	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A063581	PGDB_C024288	PGDB_AS000091	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A070760	PGDB_C024288	PGDB_AS000750	View

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