PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

CC1(C)CCC(CN2CCN(Nc3cccc4c3CN(C3CCC(=O)NC3=O)C4=O)CC2)=C(c2ccc(F)cc2)C1

Compound summary

Compound IDPGDB_C024426

FormulaC32H38FN5O3

Molecular weight559.686

InChIKeyOOOPSLLORWEKHG-UHFFFAOYSA-N

Physicochemical properties

Exact mass559.2959

RDKit cLogP4.2

TPSA85

HBD / HBA2 / 6

Rotatable bonds6

Heavy atoms41

Hetero atoms9

Rings / aromatic6 / 2

Fraction Csp30.47

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	WO2025162225A1	PGDB_A008624	PGDB_C024426	PGDB_AS000091	View
% Inhibition	-	=	30-40	%	10 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A014442	PGDB_C024426	PGDB_AS001155	View
% Degradation	-	=	20-100	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	WO2025162225A1	PGDB_A035259	PGDB_C024426	PGDB_AS000689	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	CRBN	-	WO2025162225A1	PGDB_A037829	PGDB_C024426	PGDB_AS000750	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	CRBN	-	WO2025162225A1	PGDB_A040417	PGDB_C024426	PGDB_AS001726	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	WO2025162225A1	PGDB_A042360	PGDB_C024426	PGDB_AS000351	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	CRBN	-	WO2025162225A1	PGDB_A046750	PGDB_C024426	PGDB_AS002453	View
% Inhibition	-	=	40-50	%	500 nM	96 h	IKZF3	-	MV-4-11	WO2025162225A1	PGDB_A052922	PGDB_C024426	PGDB_AS001561	View

Rows per pagePage 1 of 1 · 8 recordsGo to page