PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberAU2022419982A1

AssigneeGilead Sciences

TitleIkaros zinc finger family degraders and uses thereof

Family ID85076046

Family members13

Filing year2022

Publication date2024-06-06

JurisdictionAU

Compounds156

Activity records614

Assays4

Activity compounds and values

Activity records

614 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Dmax	-	=	67	%	-	24 h	IKZF2	-	HEK293	PGDB_A007465	PGDB_C005947	PGDB_AS000473	View
Dmax	-	=	44	%	-	24 h	IKZF1	-	HEK293	PGDB_A007700	PGDB_C005897	PGDB_AS000645	View
Dmax	-	=	27	%	-	24 h	IKZF1	-	HEK293	PGDB_A007762	PGDB_C005979	PGDB_AS000645	View
Dmax	-	=	95	%	-	24 h	IKZF1	-	HEK293	PGDB_A007890	PGDB_C005887	PGDB_AS000645	View
Dmax	-	=	88	%	-	24 h	IKZF1	-	HEK293	PGDB_A007912	PGDB_C005956	PGDB_AS000645	View
EC50	-	=	0.246	uM	-	—	IKZF1	-	HEK293	PGDB_A007928	PGDB_C005924	PGDB_AS001788	View
Dmax	-	=	55	%	-	24 h	IKZF1	-	HEK293	PGDB_A008074	PGDB_C005976	PGDB_AS000645	View
EC50	-	=	0.121	uM	-	—	IKZF1	-	HEK293	PGDB_A008108	PGDB_C006007	PGDB_AS001788	View
EC50	-	=	0.07	uM	-	—	IKZF1	-	HEK293	PGDB_A008215	PGDB_C005952	PGDB_AS001788	View
Dmax	-	=	85	%	-	24 h	IKZF2	-	HEK293	PGDB_A008493	PGDB_C005993	PGDB_AS000473	View
Dmax	-	=	97	%	-	24 h	IKZF2	-	HEK293	PGDB_A008546	PGDB_C005965	PGDB_AS000473	View
Dmax	-	=	36	%	-	24 h	IKZF1	-	HEK293	PGDB_A008625	PGDB_C005918	PGDB_AS000645	View
EC50	-	=	0.053	uM	-	—	IKZF1	-	HEK293	PGDB_A008818	PGDB_C005875	PGDB_AS001788	View
EC50	-	=	0.023	uM	-	—	IKZF1	-	HEK293	PGDB_A008884	PGDB_C005881	PGDB_AS001788	View
EC50	-	=	0.07	uM	-	—	IKZF1	-	HEK293	PGDB_A009078	PGDB_C005934	PGDB_AS001788	View
EC50	-	=	0.005	uM	-	—	IKZF1	-	HEK293	PGDB_A009136	PGDB_C006012	PGDB_AS001788	View
Dmax	-	=	36	%	-	24 h	IKZF2	-	HEK293	PGDB_A009204	PGDB_C005889	PGDB_AS000473	View
EC50	-	=	0.038	uM	-	—	IKZF1	-	HEK293	PGDB_A009210	PGDB_C005911	PGDB_AS001788	View
EC50	-	=	0.146	uM	-	—	IKZF1	-	HEK293	PGDB_A009214	PGDB_C005998	PGDB_AS001788	View
Dmax	-	=	86	%	-	24 h	IKZF2	-	HEK293	PGDB_A009513	PGDB_C006006	PGDB_AS000473	View

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