PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN121487946A

AssigneeBristol Myers Squibb

TitleSpirocyclic substituted oxo-isoindolinyl piperidine-2, 6-dione compounds

Family ID91758942

Family members6

Filing year2024

Publication date2026-02-06

JurisdictionCN

Compounds3

Activity records64

Assays22

Activity compounds and values

Activity records

64 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Dmax	-	=	28	%	-	72 h	IKZF3	-	Jurkat	PGDB_A008022	PGDB_C007382	PGDB_AS000406	View
Dmax	-	=	62-66	%	-	-	IKZF3	-	-	PGDB_A008787	PGDB_C007380	PGDB_AS002330	View
% Degradation	-	=	11	%	Concentration context: titrated doses of compound	24 h	IKZF1	-	-	PGDB_A009042	PGDB_C007382	PGDB_AS000538	View
Dmax	-	=	95	%	-	-	IKZF4	-	-	PGDB_A011201	PGDB_C007382	PGDB_AS001124	View
DC50	-	=	29-43	nM	-	—	IKZF1	-	-	PGDB_A012552	PGDB_C007380	PGDB_AS002334	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	PGDB_A013342	PGDB_C007380	PGDB_AS000978	View
Dmax	-	=	90	%	-	72 h	IKZF2	-	Jurkat	PGDB_A014214	PGDB_C007382	PGDB_AS000903	View
DC50	-	>	1000	nM	-	—	IKZF1	-	-	PGDB_A015959	PGDB_C007382	PGDB_AS002334	View
% Degradation	-	=	39	%	Concentration context: titrated doses	24 h	IKZF3	-	-	PGDB_A016920	PGDB_C007381	PGDB_AS002005	View
Dmax	-	=	64-65	%	-	-	IKZF1	-	-	PGDB_A018398	PGDB_C007380	PGDB_AS002121	View
Dmax	-	=	13	%	-	72 h	IKZF1	-	Jurkat	PGDB_A019691	PGDB_C007381	PGDB_AS002502	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	PGDB_A020151	PGDB_C007382	PGDB_AS000978	View
DC50	-	=	38	nM	-	—	IKZF2	-	-	PGDB_A020645	PGDB_C007380	PGDB_AS000973	View
DC50	-	>	1000	nM	-	—	IKZF3	-	-	PGDB_A021039	PGDB_C007381	PGDB_AS001183	View
DC50	-	=	2.9	nM	-	—	IKZF2	-	Jurkat	PGDB_A022356	PGDB_C007381	PGDB_AS001637	View
DC50	-	>	10000	nM	-	—	IKZF1	-	Jurkat	PGDB_A023192	PGDB_C007381	PGDB_AS000485	View
Dmax	-	=	92	%	-	-	IKZF2	-	-	PGDB_A024156	PGDB_C007381	PGDB_AS000749	View
Dmax	-	=	2	%	-	-	IKZF3	-	-	PGDB_A025923	PGDB_C007382	PGDB_AS002330	View
DC50	-	=	8.5	nM	-	—	IKZF2	-	Jurkat	PGDB_A028045	PGDB_C007380	PGDB_AS001637	View
Dmax	-	=	91	%	-	72 h	IKZF2	-	Jurkat	PGDB_A028277	PGDB_C007380	PGDB_AS000903	View

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