PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

Nc1nc(-c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)ccc1CN1CC2(CCC2)C1

Compound summary

Compound IDPGDB_C007382

FormulaC25H27N5O3

Molecular weight445.523

InChIKeyUZLMRMVUVTXJJP-UHFFFAOYSA-N

Physicochemical properties

Exact mass445.2114

RDKit cLogP2.08

TPSA108.6

HBD / HBA2 / 6

Rotatable bonds4

Heavy atoms33

Hetero atoms8

Rings / aromatic6 / 2

Fraction Csp30.44

Formal charge0

Fragments1

Activity compounds and values

Activity records

67 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	28	%	-	72 h	IKZF3	-	Jurkat	CN121487946A	PGDB_A008022	PGDB_C007382	PGDB_AS000406	View
Dmax	-	=	95	%	Concentration context: titrated doses	13 d	IKZF4	-	-	WO2025064197	PGDB_A008838	PGDB_C007382	PGDB_AS000221	View
% Degradation	-	=	11	%	Concentration context: titrated doses of compound	24 h	IKZF1	-	-	CN121487946A	PGDB_A009042	PGDB_C007382	PGDB_AS000538	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	WO2025064197	PGDB_A010419	PGDB_C007382	PGDB_AS002122	View
Dmax	-	=	95	%	-	-	IKZF4	-	-	CN121487946A	PGDB_A011201	PGDB_C007382	PGDB_AS001124	View
DC50	-	=	1	nM	-	—	IKZF4	-	-	CN121646585A	PGDB_A012059	PGDB_C007382	PGDB_AS000563	View
Dmax	-	=	97	%	-	20 h	IKZF2	-	-	WO2025064197	PGDB_A013616	PGDB_C007382	PGDB_AS001254	View
Dmax	-	=	90	%	-	72 h	IKZF2	-	Jurkat	CN121487946A	PGDB_A014214	PGDB_C007382	PGDB_AS000903	View
DC50	-	>	1000	nM	-	—	IKZF1	-	-	CN121487946A	PGDB_A015959	PGDB_C007382	PGDB_AS002334	View
DC50	-	=	1	nM	-	—	IKZF4	-	-	WO2025064197	PGDB_A017498	PGDB_C007382	PGDB_AS001710	View
DC50	-	=	11	nM	-	—	IKZF2	-	-	CN121646585A	PGDB_A017673	PGDB_C007382	PGDB_AS001421	View
Dmax	-	=	2	%	Concentration context: titrated doses	24 h	IKZF3	-	-	CN121646585A	PGDB_A019376	PGDB_C007382	PGDB_AS001615	View
DC50	-	>	10000	nM	-	—	IKZF3	-	Jurkat	CN121487946A	PGDB_A020151	PGDB_C007382	PGDB_AS000978	View
DC50	-	=	11	nM	-	—	IKZF2	-	-	WO2025064197	PGDB_A020884	PGDB_C007382	PGDB_AS001597	View
Dmax	-	=	48	%	-	72 h	IKZF1	-	Jurkat	CN121646585A	PGDB_A022353	PGDB_C007382	PGDB_AS000236	View
DC50	-	=	15	nM	-	—	IKZF4	-	-	WO2025064197	PGDB_A025769	PGDB_C007382	PGDB_AS001282	View
Dmax	-	=	2	%	-	-	IKZF3	-	-	CN121487946A	PGDB_A025923	PGDB_C007382	PGDB_AS002330	View
Dmax	-	=	3	%	-	24 h	IKZF3	-	-	WO2025064197	PGDB_A026045	PGDB_C007382	PGDB_AS000033	View
DC50	-	>	10000	nM	-	—	IKZF3	-	-	WO2025064197	PGDB_A028773	PGDB_C007382	PGDB_AS001891	View
Dmax	-	=	11	%	-	24 h	IKZF1	-	-	CN121646585A	PGDB_A028810	PGDB_C007382	PGDB_AS000956	View

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