PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberKR20210031680A

AssigneeNovartis

Title3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of IKAROS family zinc finger 2 (IKZF2)-dependent diseases

Family ID68136441

Family members53

Filing year2019

Publication date2021-03-22

JurisdictionKR

Compounds186

Activity records592

Assays4

Activity compounds and values

Activity records

592 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	67	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A007118	PGDB_C008906	PGDB_AS000887	View
EC50	-	=	0.002	mM	-	—	IKZF2	-	293GT	PGDB_A007134	PGDB_C008799	PGDB_AS001244	View
EC50	-	>	30	mM	-	—	GSPT1	-	293GT	PGDB_A007417	PGDB_C008909	PGDB_AS001734	View
% Degradation	-	=	0.77	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A007441	PGDB_C008811	PGDB_AS000887	View
EC50	-	>	30	mM	-	—	IKZF1	-	293GT	PGDB_A007460	PGDB_C008781	PGDB_AS002284	View
EC50	-	>	30	mM	-	—	IKZF1	-	293GT	PGDB_A007463	PGDB_C008916	PGDB_AS002284	View
% Degradation	-	=	0	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A007554	PGDB_C008787	PGDB_AS000887	View
% Degradation	-	=	0.75	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A007654	PGDB_C008829	PGDB_AS000887	View
EC50	-	=	0.085	mM	-	—	IKZF2	-	293GT	PGDB_A007708	PGDB_C008841	PGDB_AS001244	View
EC50	-	>	30	mM	-	—	IKZF1	-	293GT	PGDB_A007864	PGDB_C008820	PGDB_AS002284	View
EC50	-	>	30	mM	-	—	IKZF1	-	293GT	PGDB_A008006	PGDB_C008860	PGDB_AS002284	View
EC50	-	>	30	mM	-	—	IKZF1	-	293GT	PGDB_A008134	PGDB_C008771	PGDB_AS002284	View
EC50	-	>	30	mM	-	—	IKZF1	-	293GT	PGDB_A008297	PGDB_C008903	PGDB_AS002284	View
% Degradation	-	=	85	%	10 uM	24 h	IKZF2	-	293GT	PGDB_A008650	PGDB_C008924	PGDB_AS000887	View
EC50	-	>	30	mM	-	—	IKZF1	-	293GT	PGDB_A009024	PGDB_C008875	PGDB_AS002284	View
EC50	-	>	30	mM	-	—	IKZF1	-	293GT	PGDB_A009100	PGDB_C008886	PGDB_AS002284	View
EC50	-	=	0.018	mM	-	—	IKZF2	-	293GT	PGDB_A009126	PGDB_C008771	PGDB_AS001244	View
EC50	-	=	0.077	mM	-	—	IKZF2	-	293GT	PGDB_A009132	PGDB_C008830	PGDB_AS001244	View
EC50	-	=	0.007	mM	-	—	IKZF2	-	293GT	PGDB_A009171	PGDB_C008792	PGDB_AS001244	View
EC50	-	=	0.136	mM	-	—	IKZF2	-	293GT	PGDB_A009249	PGDB_C008870	PGDB_AS001244	View

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