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Patent
US20220362229A1
74 compounds121 activity records3 assays
Patent summary
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 | % Inhibition | - | = | 46.7 | % | 200 uM | - | - | - | - | PGDB_A007419 | PGDB_C009092 | PGDB_AS001773 | View |
 | % Degradation | - | = | 106.5 | % | Concentration series: 10 nM, 10 uM | - | CRBN | CRBN | - | PGDB_A008745 | PGDB_C009131 | PGDB_AS002247 | View |
 | % Inhibition | - | = | 18.4 | % | 200 uM | - | - | - | - | PGDB_A009837 | PGDB_C009095 | PGDB_AS001773 | View |
 | % Inhibition | - | = | 79.62 | % | 200 uM | - | - | - | - | PGDB_A009976 | PGDB_C009079 | PGDB_AS001773 | View |
 | % Degradation | - | = | 91.11 | % | Concentration series: 10 nM, 10 uM | - | CRBN | CRBN | - | PGDB_A010031 | PGDB_C009083 | PGDB_AS002247 | View |
 | % Inhibition | - | = | 18 | % | 200 uM | - | - | - | - | PGDB_A010497 | PGDB_C009070 | PGDB_AS001773 | View |
 | Kd | - | = | 13.56 | uM | - | — | CRBN | CRBN | - | PGDB_A011274 | PGDB_C009123 | PGDB_AS002291 | View |
 | Kd | - | = | 11.15 | uM | - | — | CRBN | CRBN | - | PGDB_A011461 | PGDB_C009077 | PGDB_AS002291 | View |
 | % Degradation | - | = | 38.07 | % | Concentration series: 10 nM, 10 uM | - | CRBN | CRBN | - | PGDB_A011858 | PGDB_C009099 | PGDB_AS002247 | View |
 | % Degradation | - | = | 36.53 | % | Concentration series: 10 nM, 10 uM | - | CRBN | CRBN | - | PGDB_A012112 | PGDB_C009075 | PGDB_AS002247 | View |
 | % Degradation | - | = | 103.81 | % | Concentration series: 10 nM, 10 uM | - | CRBN | CRBN | - | PGDB_A012330 | PGDB_C009065 | PGDB_AS002247 | View |
 | % Inhibition | - | = | 57.2 | % | 200 uM | - | - | - | - | PGDB_A012370 | PGDB_C009091 | PGDB_AS001773 | View |
 | % Degradation | - | = | 82.18 | % | Concentration series: 10 nM, 10 uM | - | CRBN | CRBN | - | PGDB_A012496 | PGDB_C009107 | PGDB_AS002247 | View |
 | Kd | - | = | 23.64 | uM | - | — | CRBN | CRBN | - | PGDB_A013161 | PGDB_C009088 | PGDB_AS002291 | View |
 | % Degradation | - | = | 6.19 | % | Concentration series: 10 nM, 10 uM | - | CRBN | CRBN | - | PGDB_A013324 | PGDB_C009072 | PGDB_AS002247 | View |
 | Kd | - | = | 2.53 | uM | - | — | CRBN | CRBN | - | PGDB_A013951 | PGDB_C009096 | PGDB_AS002291 | View |
 | % Degradation | - | = | 153.23 | % | Concentration series: 10 nM, 10 uM | - | CRBN | CRBN | - | PGDB_A014073 | PGDB_C009134 | PGDB_AS002247 | View |
 | Kd | - | = | 15.25 | uM | - | — | CRBN | CRBN | - | PGDB_A015160 | PGDB_C009084 | PGDB_AS002291 | View |
 | % Degradation | - | = | 9.54 | % | Concentration series: 10 nM, 10 uM | - | CRBN | CRBN | - | PGDB_A015499 | PGDB_C009094 | PGDB_AS002247 | View |
 | % Degradation | - | = | 157.27 | % | Concentration series: 10 nM, 10 uM | - | CRBN | CRBN | - | PGDB_A016051 | PGDB_C009118 | PGDB_AS002247 | View |