PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2025199151A1

AssigneeNeosphere Biotechnologies, St Jude Childrens Research Hospital

TitleSmall molecule cereblon binders that induce the degradation of proteins (kdm4b, vcl) relevant to cancer

Family ID97140138

Family members1

Filing year2025

Publication date2025-09-25

JurisdictionWO

Compounds13

Activity records16

Assays4

Activity compounds and values

Activity records

16 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Degradation	-	=	52	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A007627	PGDB_C011577	PGDB_AS001565	View
% Degradation	-	=	16	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A013790	PGDB_C011581	PGDB_AS001565	View
DC50	-	=	116	nM	-	—	VCL	-	BE2C	PGDB_A024517	PGDB_C011574	PGDB_AS002418	View
% Degradation	-	=	76	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A028115	PGDB_C011580	PGDB_AS001565	View
% Degradation	-	=	65	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A041086	PGDB_C011586	PGDB_AS001565	View
% Degradation	-	=	78	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A041372	PGDB_C011575	PGDB_AS001565	View
% Degradation	-	=	59	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A042011	PGDB_C011582	PGDB_AS001565	View
% Degradation	-	=	44	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A042226	PGDB_C011578	PGDB_AS001565	View
% Degradation	-	=	21	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A043479	PGDB_C011584	PGDB_AS001565	View
% Degradation	-	=	73	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A044458	PGDB_C011583	PGDB_AS001565	View
% Degradation	-	=	45	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A049369	PGDB_C011579	PGDB_AS001565	View
% Degradation	-	=	90	%	1 uM	24 h	VCL	-	BE2C	PGDB_A057596	PGDB_C011574	PGDB_AS001898	View
% Degradation	-	=	74	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A058897	PGDB_C011585	PGDB_AS001565	View
% Degradation	-	=	58	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A064647	PGDB_C011576	PGDB_AS001565	View
% Degradation	-	=	0	%	0.1 uM	24 h	KDM4B	-	BE2C	PGDB_A068473	PGDB_C011574	PGDB_AS001565	View
DC50	-	=	40	nM	-	—	KDM4B	-	BE2C	PGDB_A075377	PGDB_C011575	PGDB_AS001721	View

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