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SIMM · NJU
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SIMM · NJU
Patent
WO2026061428A1
63 compounds
128 activity records
5 assays
Patent summary
Publication number
WO2026061428A1
Assignee
Shanghai Meiyue Biotech Development Co Ltd
Title
Fused ring compound and pharmaceutical composition comprising same and use thereof
Family members
1
Family patent IDs
WO2026061428A1
Filing year
2025
Publication date
2026-03-26
Jurisdiction
WO
Compounds
63
Activity records
128
Assays
5
Activity compounds and values
Activity records
125 records
Structure
Metric
Control
Relation
Value
Unit
Concentration
Time
Target
E3
Cell line
Record ID
Compound
Assay
Details
Dmax
-
=
92
%
Concentration range: 1000 nM
-
VAV1
-
Jurkat
PGDB_A000048
PGDB_C024745
PGDB_AS000765
View
Dmax
-
=
96.1
%
Concentration range: 1000 nM
-
VAV1
-
Jurkat
PGDB_A000067
PGDB_C024811
PGDB_AS000765
View
Dmax
-
=
88.5
%
Concentration range: 1000 nM
-
VAV1
-
Jurkat
PGDB_A000198
PGDB_C024742
PGDB_AS000765
View
DC50
-
<=
50
nM
-
—
VAV1
-
Jurkat
PGDB_A000236
PGDB_C030185
PGDB_AS001390
View
Dmax
-
=
103.9
%
Concentration range: 1000 nM
-
VAV1
-
Jurkat
PGDB_A000247
PGDB_C024818
PGDB_AS000765
View
Dmax
-
=
96.9
%
Concentration range: 1000 nM
-
VAV1
-
Jurkat
PGDB_A000327
PGDB_C024817
PGDB_AS000765
View
Dmax
-
=
96.6
%
Concentration range: 1000 nM
-
VAV1
-
Jurkat
PGDB_A000331
PGDB_C030155
PGDB_AS000765
View
DC50
-
<=
50
nM
-
—
VAV1
-
Jurkat
PGDB_A000482
PGDB_C024824
PGDB_AS001390
View
Dmax
-
=
100
%
Concentration range: 1000 nM
-
VAV1
-
Jurkat
PGDB_A000486
PGDB_C024758
PGDB_AS000765
View
DC50
-
<=
50
nM
-
—
VAV1
-
Jurkat
PGDB_A000692
PGDB_C024762
PGDB_AS001390
View
DC50
-
<=
50
nM
-
—
VAV1
-
Jurkat
PGDB_A000926
PGDB_C024741
PGDB_AS001390
View
DC50
-
<=
50
nM
-
—
VAV1
-
Jurkat
PGDB_A001038
PGDB_C024754
PGDB_AS001390
View
Dmax
-
=
97.8
%
Concentration range: 1000 nM
-
VAV1
-
Jurkat
PGDB_A001044
PGDB_C024762
PGDB_AS000765
View
DC50
-
=
50-500
nM
-
—
VAV1
-
Jurkat
PGDB_A001346
PGDB_C024752
PGDB_AS001390
View
Dmax
-
=
95.62
%
Concentration range: 1000 nM
-
VAV1
-
Jurkat
PGDB_A001431
PGDB_C010388
PGDB_AS000765
View
DC50
-
<=
50
nM
-
—
VAV1
-
Jurkat
PGDB_A001451
PGDB_C024760
PGDB_AS001390
View
DC50
-
<=
50
nM
-
—
VAV1
-
Jurkat
PGDB_A001485
PGDB_C024815
PGDB_AS001390
View
DC50
-
<=
50
nM
-
—
VAV1
-
Jurkat
PGDB_A001531
PGDB_C024805
PGDB_AS001390
View
DC50
-
<=
50
nM
-
—
VAV1
-
Jurkat
PGDB_A001591
PGDB_C024822
PGDB_AS001390
View
DC50
-
<=
50
nM
-
—
VAV1
-
Jurkat
PGDB_A001688
PGDB_C024745
PGDB_AS001390
View
