PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(NC(=O)N4CC5(CCOCC5)c5ccccc54)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C010388

FormulaC26H26N4O5

Molecular weight474.517

InChIKeyXFTKTXZPWJMLPJ-UHFFFAOYSA-N

Physicochemical properties

Exact mass474.1903

RDKit cLogP2.55

TPSA108

HBD / HBA2 / 5

Rotatable bonds2

Heavy atoms35

Hetero atoms9

Rings / aromatic6 / 2

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

14 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
Dmax	-	=	95.62	%	Concentration range: 1000 nM	-	VAV1	-	Jurkat	WO2026061428A1	PGDB_A001431	PGDB_C010388	PGDB_AS000765	View
DC50	-	=	4	nM	-	—	NEK7	-	CAL-51	WO2025024521A1	PGDB_A007836	PGDB_C010388	PGDB_AS001365	View
DC50	-	<	0.5	uM	-	—	SMARCA2	-	HeLa	WO2025101944	PGDB_A010397	PGDB_C010388	PGDB_AS000900	View
GI50	-	<=	0.1	uM	-	—	-	-	LS180	EP4540240A1	PGDB_A010843	PGDB_C010388	PGDB_AS001295	View
EC50	-	=	0.07	uM	-	—	CRBN	CRBN	-	WO2025024521A1	PGDB_A021754	PGDB_C010388	PGDB_AS001033	View
% Degradation	-	=	0-20	%	-	-	-	-	-	US20220213115A1	PGDB_A024617	PGDB_C010388	PGDB_AS000884	View
DC50	-	=	0.5-5	uM	-	—	SMARCA4	-	HeLa	WO2025101944	PGDB_A036112	PGDB_C010388	PGDB_AS000431	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA4	-	HeLa	WO2025101944	PGDB_A046031	PGDB_C010388	PGDB_AS002120	View
GI50	-	<=	0.1	uM	-	—	-	-	LS174T	EP4540240A1	PGDB_A048684	PGDB_C010388	PGDB_AS000256	View
% Degradation	-	=	30-70	%	1 uM	24 h	SMARCA2	-	HeLa	WO2025101944	PGDB_A066596	PGDB_C010388	PGDB_AS001961	View
DC50	-	<=	0.1	uM	-	—	-	-	-	US20220213115A1	PGDB_A068609	PGDB_C010388	PGDB_AS000741	View
Dmax	-	=	94	%	Concentration series: 1 uM, 0.05 nM	24 h	NEK7	-	CAL-51	WO2025024521A1	PGDB_A068628	PGDB_C010388	PGDB_AS002061	View
GI50	-	<=	0.1	uM	-	—	-	-	GP2D	EP4540240A1	PGDB_A075281	PGDB_C010388	PGDB_AS000507	View
DC50	-	<=	50	nM	-	—	VAV1	-	Jurkat	WO2026061428A1	PGDB_A081456	PGDB_C010388	PGDB_AS001390	View

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