PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberWO2026119184

AssigneeNorthridge Health Group Hong Kong

TitlePTPN2/PTP1B DEGRADERS AND THERAPEUTIC METHOD THEREOF

Family IDpdf_only_WO2026119184

Family members1

Filing year2025

Publication date2026-06-11

JurisdictionWO

Compounds16

Activity records80

Assays10

Activity compounds and values

Activity records

80 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
Selectivity index	N2/1B	=	4.2	fold	-	—	-	-	HCT116	PGDB_A007517	PGDB_C028707	PGDB_AS000119	View
Selectivity index	N2/1B	=	3.84	fold	-	—	-	-	HCT116	PGDB_A007658	PGDB_C028711	PGDB_AS000119	View
Dmax	-	=	98.5	%	-	-	-	-	HCT116	PGDB_A007754	PGDB_C028710	PGDB_AS000959	View
DC50	-	=	10.34	nM	-	—	-	-	HCT116	PGDB_A009773	PGDB_C028714	PGDB_AS000045	View
DC50	-	=	13.86	nM	-	—	PTPN1	-	-	PGDB_A010490	PGDB_C028704	PGDB_AS000433	View
DC50	-	=	5.76	nM	-	—	-	-	HCT116	PGDB_A011343	PGDB_C028707	PGDB_AS000045	View
Dmax	-	=	96.9	%	-	-	PTPN1	-	-	PGDB_A011522	PGDB_C028704	PGDB_AS002412	View
Dmax	-	=	97.5	%	-	-	-	-	HCT116	PGDB_A011548	PGDB_C028712	PGDB_AS000736	View
Selectivity index	N2/1B	=	2.36	fold	-	—	-	-	-	PGDB_A012442	PGDB_C028705	PGDB_AS001537	View
Dmax	-	=	92.3	%	-	-	-	-	HCT116	PGDB_A013554	PGDB_C028713	PGDB_AS000959	View
Dmax	-	=	98.9	%	-	-	-	-	HCT116	PGDB_A014529	PGDB_C028711	PGDB_AS000959	View
Selectivity index	N2/1B	=	3.16	fold	-	—	-	-	HCT116	PGDB_A014603	PGDB_C028713	PGDB_AS000119	View
DC50	-	=	5.4	nM	-	—	-	-	-	PGDB_A015936	PGDB_C028701	PGDB_AS002400	View
Selectivity index	N2/1B	=	3.61	fold	-	—	-	-	HCT116	PGDB_A016060	PGDB_C028714	PGDB_AS000119	View
Dmax	-	=	99.8	%	-	-	-	-	HCT116	PGDB_A016629	PGDB_C028709	PGDB_AS000959	View
Dmax	-	=	97.1	%	-	-	PTPN1	-	-	PGDB_A017037	PGDB_C028705	PGDB_AS002412	View
DC50	-	=	92.26	nM	-	—	PTPN1	-	HCT116	PGDB_A017571	PGDB_C028713	PGDB_AS001836	View
DC50	-	=	10.77	nM	-	—	-	-	-	PGDB_A018345	PGDB_C028705	PGDB_AS002400	View
DC50	-	=	29.11	nM	-	—	-	-	HCT116	PGDB_A019481	PGDB_C028713	PGDB_AS000045	View
Selectivity index	N2/1B	=	1.47	fold	-	—	-	-	-	PGDB_A021708	PGDB_C028706	PGDB_AS001537	View

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