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Compound
PGDB_C000357
5 activity records1 related patents
2D structure
O=C(C#Cc1ccc(-c2ccccc2)cc1)NCc1ccc2c(c1)CN(C1CCC(=O)NC1=O)C2=OCompound summary
Physicochemical properties
Activity compounds and values
Activity records
| Structure | Control | Value | Concentration | Time | Record ID | Compound | Assay | Details | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| IC50 | - | = | 5.3 | nM | - | — | - | - | THP-1 | CN117683022A | PGDB_A011310 | PGDB_C000357 | PGDB_AS000289 | View |
| Apoptosis | - | > | 60 | % | - | — | - | - | - | CN117683022A | PGDB_A018415 | PGDB_C000357 | PGDB_AS001538 | View |
| % Degradation | - | = | 30-60 | % | 1 uM | - | BRD4 | - | - | CN117683022A | PGDB_A047653 | PGDB_C000357 | PGDB_AS002272 | View |
| IC50 | - | < | 200 | nM | - | — | - | - | Raji | CN117683022A | PGDB_A060890 | PGDB_C000357 | PGDB_AS000751 | View |
| % Degradation | - | = | 80-100 | % | 1 uM | - | GSPT1 | - | - | CN117683022A | PGDB_A069738 | PGDB_C000357 | PGDB_AS001783 | View |