PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN117683022A

AssigneeBeijing Hospital

TitleAn amide compound and its preparation method and application

Family ID90129673

Family members1

Filing year2023

Publication date2024-03-12

JurisdictionCN

Compounds21

Activity records85

Assays5

Activity compounds and values

Activity records

85 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
IC50	-	=	2000-4000	nM	-	—	-	-	THP-1	PGDB_A008269	PGDB_C000343	PGDB_AS000289	View
IC50	-	=	2000-4000	nM	-	—	-	-	THP-1	PGDB_A008760	PGDB_C000352	PGDB_AS000289	View
% Degradation	-	=	30-60	%	1 uM	-	BRD4	-	-	PGDB_A009721	PGDB_C000346	PGDB_AS002272	View
% Degradation	-	=	60-80	%	1 uM	-	GSPT1	-	-	PGDB_A010675	PGDB_C000355	PGDB_AS001783	View
IC50	-	=	5.3	nM	-	—	-	-	THP-1	PGDB_A011310	PGDB_C000357	PGDB_AS000289	View
IC50	-	=	2000-4000	nM	-	—	-	-	THP-1	PGDB_A011689	PGDB_C000351	PGDB_AS000289	View
IC50	-	=	200-2000	nM	-	—	-	-	Raji	PGDB_A011896	PGDB_C000344	PGDB_AS000751	View
% Degradation	-	=	10-30	%	1 uM	-	GSPT1	-	-	PGDB_A011973	PGDB_C000340	PGDB_AS001783	View
% Degradation	-	=	10-30	%	1 uM	-	GSPT1	-	-	PGDB_A013934	PGDB_C000348	PGDB_AS001783	View
IC50	-	=	200-2000	nM	-	—	-	-	Raji	PGDB_A014595	PGDB_C000343	PGDB_AS000751	View
% Degradation	-	=	30-60	%	1 uM	-	BRD4	-	-	PGDB_A016873	PGDB_C000354	PGDB_AS002272	View
Apoptosis	-	>	60	%	-	—	-	-	-	PGDB_A018415	PGDB_C000357	PGDB_AS001538	View
% Degradation	-	=	10-30	%	1 uM	-	BRD4	-	-	PGDB_A019080	PGDB_C000059	PGDB_AS002272	View
IC50	-	>	4000	nM	-	—	-	-	Raji	PGDB_A020158	PGDB_C000059	PGDB_AS000751	View
% Degradation	-	=	30-60	%	1 uM	-	BRD4	-	-	PGDB_A021516	PGDB_C000353	PGDB_AS002272	View
IC50	-	=	200-2000	nM	-	—	-	-	Raji	PGDB_A023328	PGDB_C000352	PGDB_AS000751	View
% Degradation	-	=	30-60	%	1 uM	-	GSPT1	-	-	PGDB_A023402	PGDB_C000347	PGDB_AS001783	View
IC50	-	=	2000-4000	nM	-	—	-	-	THP-1	PGDB_A024894	PGDB_C000341	PGDB_AS000289	View
IC50	-	>	4000	nM	-	—	-	-	THP-1	PGDB_A024897	PGDB_C000059	PGDB_AS000289	View
IC50	-	=	67.3	nM	-	—	-	-	Raji	PGDB_A026802	PGDB_C000356	PGDB_AS000751	View

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