PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2C(=O)c3ccc(CN4CCC(N5CCN(C(c6ccccc6)c6ccccn6)CC5)C(F)(F)C4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000780

FormulaC34H35F2N7O4

Molecular weight643.695

InChIKeyHTSQXCSFCRLMAB-UHFFFAOYSA-N

Physicochemical properties

Exact mass643.2719

RDKit cLogP3.15

TPSA109.4

HBD / HBA1 / 8

Rotatable bonds7

Heavy atoms47

Hetero atoms13

Rings / aromatic7 / 3

Fraction Csp30.38

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A007971	PGDB_C000780	PGDB_AS002025	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A019344	PGDB_C000780	PGDB_AS001655	View
% Inhibition	-	=	30-40	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A029032	PGDB_C000780	PGDB_AS000125	View
% Inhibition	-	=	40-50	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A043988	PGDB_C000780	PGDB_AS000584	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A050947	PGDB_C000780	PGDB_AS000946	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A051320	PGDB_C000780	PGDB_AS001466	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A069901	PGDB_C000780	PGDB_AS001449	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A071618	PGDB_C000780	PGDB_AS000102	View

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