PatGlueDB | Molecular Glue Patent Bioactivity Database

Patent summary

Publication numberCN120548310A

AssigneeGluetacs Therapeutics Shanghai

TitleCompounds having a dinitrogen heterocycle-substituted isoindolinone skeleton and their applications

Family ID96216810

Family members2

Filing year2024

Publication date2025-08-26

JurisdictionCN

Compounds257

Activity records2,081

Assays42

Activity compounds and values

Activity records

2,081 records

	Control		Value		Concentration	Time				Record ID	Compound	Assay	Details
% Inhibition	-	=	40-50	%	0.1 uM	24 h	-	-	-	PGDB_A007035	PGDB_C000804	PGDB_AS000584	View
% Inhibition	-	=	20-30	%	0.1 uM	24 h	-	-	-	PGDB_A007042	PGDB_C000991	PGDB_AS002390	View
% Inhibition	-	=	30-40	%	0.1 uM	24 h	-	-	-	PGDB_A007056	PGDB_C000799	PGDB_AS000584	View
% Inhibition	-	=	10-20	%	0.5 uM	-	CRBN	CRBN	-	PGDB_A007060	PGDB_C000853	PGDB_AS002000	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	PGDB_A007063	PGDB_C000851	PGDB_AS001466	View
% Inhibition	-	=	40-53	%	0.5 uM	-	CRBN	CRBN	-	PGDB_A007158	PGDB_C000939	PGDB_AS002000	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	PGDB_A007169	PGDB_C000837	PGDB_AS000946	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	PGDB_A007185	PGDB_C000747	PGDB_AS000102	View
% Inhibition	-	=	40-50	%	500 nM	-	-	-	SW620	PGDB_A007315	PGDB_C000839	PGDB_AS001503	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	PGDB_A007322	PGDB_C000863	PGDB_AS002025	View
IC50	-	<=	2	nM	-	—	-	-	Jurkat	PGDB_A007355	PGDB_C000754	PGDB_AS000498	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	PGDB_A007375	PGDB_C000961	PGDB_AS000946	View
% Inhibition	-	=	50-60	%	1 uM	24 h	-	-	-	PGDB_A007412	PGDB_C000992	PGDB_AS000296	View
IC50	-	=	1-1.5	uM	-	—	CRBN	CRBN	-	PGDB_A007424	PGDB_C000778	PGDB_AS000323	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	PGDB_A007450	PGDB_C000795	PGDB_AS001466	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	PGDB_A007469	PGDB_C000795	PGDB_AS001655	View
IC50	-	=	10-20	nM	-	—	-	-	T47D	PGDB_A007572	PGDB_C000754	PGDB_AS001713	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	PGDB_A007663	PGDB_C000874	PGDB_AS002025	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	PGDB_A007778	PGDB_C000935	PGDB_AS000946	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	PGDB_A007793	PGDB_C000752	PGDB_AS000102	View

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