PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2Cc3cc(CN4CCC(N5CCN(c6noc7cc(F)ccc67)CC5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000785

FormulaC29H32FN7O4

Molecular weight561.618

InChIKeyPWUAOPGKBHLAFB-UHFFFAOYSA-N

Physicochemical properties

Exact mass561.25

RDKit cLogP2.57

TPSA105.5

HBD / HBA1 / 8

Rotatable bonds5

Heavy atoms41

Hetero atoms12

Rings / aromatic7 / 3

Fraction Csp30.45

Formal charge0

Fragments1

Activity compounds and values

Activity records

12 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A017307	PGDB_C000785	PGDB_AS000102	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A018942	PGDB_C000785	PGDB_AS001466	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A022108	PGDB_C000785	PGDB_AS001655	View
% Inhibition	-	=	40-50	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A028841	PGDB_C000785	PGDB_AS002390	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A028930	PGDB_C000785	PGDB_AS000946	View
% Inhibition	-	=	40-50	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A046449	PGDB_C000785	PGDB_AS000296	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A057704	PGDB_C000785	PGDB_AS002025	View
% Inhibition	-	=	50-60	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A061373	PGDB_C000785	PGDB_AS000125	View
% Inhibition	-	=	40-50	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A064443	PGDB_C000785	PGDB_AS001714	View
% Inhibition	-	=	30-40	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A069906	PGDB_C000785	PGDB_AS000115	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A073133	PGDB_C000785	PGDB_AS001449	View
% Inhibition	-	=	60-70	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A077633	PGDB_C000785	PGDB_AS000584	View

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