PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCN(N2C(=O)c3ccc(CN4CCC(N5CCC(c6noc7cc(F)ccc67)CC5)C(F)(F)C4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000789

FormulaC30H29F3N6O5

Molecular weight610.593

InChIKeyQYZMPLANUZVTTD-UHFFFAOYSA-N

Physicochemical properties

Exact mass610.2152

RDKit cLogP3.51

TPSA119.3

HBD / HBA1 / 8

Rotatable bonds5

Heavy atoms44

Hetero atoms14

Rings / aromatic7 / 3

Fraction Csp30.43

Formal charge0

Fragments1

Activity compounds and values

Activity records

8 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A010993	PGDB_C000789	PGDB_AS001655	View
% Inhibition	-	=	40-50	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A012575	PGDB_C000789	PGDB_AS000584	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A023571	PGDB_C000789	PGDB_AS000102	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A026995	PGDB_C000789	PGDB_AS000946	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A030875	PGDB_C000789	PGDB_AS001466	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A039084	PGDB_C000789	PGDB_AS002025	View
% Inhibition	-	=	30-40	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A062483	PGDB_C000789	PGDB_AS000125	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A069022	PGDB_C000789	PGDB_AS001449	View

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