PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2C(=O)c3ccc(CN4CCC(N5CCN(C(c6ccccc6)c6ccccn6)CC5)C(F)(F)C4)cc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000799

FormulaC35H36F2N6O4

Molecular weight642.707

InChIKeySLTXQYNBWKZLCE-UHFFFAOYSA-N

Physicochemical properties

Exact mass642.2766

RDKit cLogP3.1

TPSA106.2

HBD / HBA1 / 8

Rotatable bonds7

Heavy atoms47

Hetero atoms12

Rings / aromatic7 / 3

Fraction Csp30.4

Formal charge0

Fragments1

Activity compounds and values

Activity records

10 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Inhibition	-	=	30-40	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A007056	PGDB_C000799	PGDB_AS000584	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A012703	PGDB_C000799	PGDB_AS002025	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A014583	PGDB_C000799	PGDB_AS000102	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A030792	PGDB_C000799	PGDB_AS001655	View
% Inhibition	-	=	30-40	%	0.1 uM	24 h	-	-	-	CN120548310A	PGDB_A048796	PGDB_C000799	PGDB_AS001320	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A050391	PGDB_C000799	PGDB_AS001449	View
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A058147	PGDB_C000799	PGDB_AS001466	View
% Inhibition	-	=	40-50	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A066626	PGDB_C000799	PGDB_AS000125	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A069280	PGDB_C000799	PGDB_AS000946	View
% Inhibition	-	=	40-50	%	1 uM	24 h	-	-	-	CN120548310A	PGDB_A073035	PGDB_C000799	PGDB_AS000157	View

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