PatGlueDB | Molecular Glue Patent Bioactivity Database

2D structure

O=C1CCC(N2Cc3cc(C(=O)N4CCC(N5CCN(c6cccc(Cl)c6Cl)CC5)CC4)ccc3C2=O)C(=O)N1

Compound summary

Compound IDPGDB_C000908

FormulaC29H31Cl2N5O4

Molecular weight584.504

InChIKeyKUSBNKUMNNLRBJ-UHFFFAOYSA-N

Physicochemical properties

Exact mass583.1753

RDKit cLogP3.18

TPSA93.3

HBD / HBA1 / 6

Rotatable bonds4

Heavy atoms40

Hetero atoms11

Rings / aromatic6 / 2

Fraction Csp30.45

Formal charge0

Fragments1

Activity compounds and values

Activity records

6 records

	Control		Value		Concentration	Time					Record ID	Compound	Assay	Details
% Degradation	-	>=	20	%	Concentration series: 500 nM, 50 nM	24 h	GSPT1	-	-	CN120548310A	PGDB_A008786	PGDB_C000908	PGDB_AS001466	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF3	-	-	CN120548310A	PGDB_A009799	PGDB_C000908	PGDB_AS000102	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	CSNK1A1	-	-	CN120548310A	PGDB_A019236	PGDB_C000908	PGDB_AS001449	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF2	-	-	CN120548310A	PGDB_A025179	PGDB_C000908	PGDB_AS002025	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	WEE1	-	-	CN120548310A	PGDB_A026735	PGDB_C000908	PGDB_AS001655	View
% Degradation	-	=	0-20	%	Concentration series: 500 nM, 50 nM	24 h	IKZF1	-	-	CN120548310A	PGDB_A028970	PGDB_C000908	PGDB_AS000946	View

Rows per pagePage 1 of 1 · 6 recordsGo to page